Invention Grant
US09540638B2 Lipid particle, nucleic acid transfer carrier, compound for manufacturing nucleic acid transfer carrier, method for manufacturing lipid particle, and gene transfer method
有权
脂质颗粒,核酸转运载体,用于制造核酸转移载体的化合物,脂质颗粒的制造方法和基因转移方法
- Patent Title: Lipid particle, nucleic acid transfer carrier, compound for manufacturing nucleic acid transfer carrier, method for manufacturing lipid particle, and gene transfer method
- Patent Title (中): 脂质颗粒,核酸转运载体,用于制造核酸转移载体的化合物,脂质颗粒的制造方法和基因转移方法
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Application No.: US14314873Application Date: 2014-06-25
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Publication No.: US09540638B2Publication Date: 2017-01-10
- Inventor: Naoyuki Nishikawa , Kyoko Senga , Yuuki Inoue , Yuko Igarashi
- Applicant: FUJIFILM Corporation
- Applicant Address: JP Tokyo
- Assignee: FUJIFILM Corporation
- Current Assignee: FUJIFILM Corporation
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2013-133620 20130626
- Main IPC: C12N15/11
- IPC: C12N15/11

Abstract:
The present invention provides a lipid particle which has low cytotoxicity, can stably hold a nucleic acid molecule outside a cell (in blood), and can escape from an endosome and rapidly release the nucleic acid in the cytoplasm; a nucleic acid transfer carrier; a compound for manufacturing a nucleic acid transfer carrier; a method for manufacturing a lipid particle; and a gene transfer method. The lipid particle contains, as constituents, a phospholipid having one or more amino groups and one or more nitrogen-containing heterocyclic groups, a neutral lipid not containing a nitrogen-containing heterocyclic group, a sterol, and a nucleic acid.
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