Invention Grant
US09540651B2 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
有权
免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答
- Patent Title: Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
- Patent Title (中): 免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答
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Application No.: US14791749Application Date: 2015-07-06
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Publication No.: US09540651B2Publication Date: 2017-01-10
- Inventor: Ekambar R. Kandimalla , Daqing Wang , Ireneusz Nowak , Sudhir Agrawal
- Applicant: Idera Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph C. Zucchero; Carolyn S. Elmore
- Main IPC: A61K31/7115
- IPC: A61K31/7115 ; C12N15/117 ; A61K45/06
Abstract:
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Public/Granted literature
- US20160215287A1 IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE Public/Granted day:2016-07-28
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