Methods and structure for selective cache mirroring. One embodiment includes a control unit and a memory. The memory is able to store indexing information for a multi-device cache for a logical volume. The control unit is able to receive an Input/Output (I/O) request from a host directed to a Logical Block Address (LBA) of the logical volume, to consult the indexing information to identify a cache line for storing the I/O request, and to store the I/O request at the cache line on a first device of the cache. The control unit is further able to mirror the I/O request to another device of the cache if the I/O request is a write request, and to complete the I/O request without mirroring the I/O request to another device of the cache if the I/O request is a read request.