Disclosed is an optical time-stamping device, including an optical instrument with a retina having a field of view and being able to produce on the retina images of the field of view, and a high accuracy reference clock signal receive. The time-stamping device also includes: a lighting source at a distance from the retina of an optical instrument, and configured to emit a light signal in the direction of the retina of an optical instrument and in the field of view of an optical instrument, and a control unit connected to the reference clock signal receiver by a first connection and to the lighting source by a second connection, and configured for controlling the lighting source for emitting a light signal in a synchronized way with the reference clock signal. An associated image sensing system and optical time-stamping method are also disclosed.