Invention Grant
- Patent Title: Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
- Patent Title (中): 结合表皮生长因子受体的可活化抗体及其使用方法
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Application No.: US14815111Application Date: 2015-07-31
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Publication No.: US09545442B2Publication Date: 2017-01-17
- Inventor: Henry Bernard Lowman , Luc Roland Desnoyers , Shouchun Liu , James William West , Jason Gary Sagert , Olga Vasiljeva , Elizabeth-Edna Mary Menendez
- Applicant: CytomX Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: CYTOMX THERAPEUTICS, INC.
- Current Assignee: CYTOMX THERAPEUTICS, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Cooley LLP
- Agent Ivor R. Elrifi
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; A61K39/395 ; C07K16/28 ; A61K47/48 ; A61K49/00 ; C07K16/30 ; G01N33/574 ; A61K39/00
Abstract:
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
Public/Granted literature
- US20160193332A1 Activatable Antibodies That Bind Epidermal Growth Factor Receptor And Methods Of Use Thereof Public/Granted day:2016-07-07
Information query
