Invention Grant
- Patent Title: CXCR4 inhibiting carriers for nucleic acid delivery
- Patent Title (中): 用于核酸递送的CXCR4抑制载体
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Application No.: US14351789Application Date: 2012-10-15
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Publication No.: US09545453B2Publication Date: 2017-01-17
- Inventor: David Oupicky , Jing Li
- Applicant: Wayne State University
- Applicant Address: US MI Detroit
- Assignee: Wayne State University
- Current Assignee: Wayne State University
- Current Assignee Address: US MI Detroit
- Agency: Senniger Powers LLP
- International Application: PCT/US2012/060292 WO 20121015
- International Announcement: WO2013/056250 WO 20130418
- Main IPC: A61K31/713
- IPC: A61K31/713 ; A61K31/7105 ; A61K31/395 ; C07D257/02 ; A61K48/00 ; A61K47/48 ; C08G69/26 ; C08G73/02 ; C08G73/06 ; A61K51/04 ; A61K51/06 ; C08G63/685 ; C12N15/87 ; A61K38/12
Abstract:
The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical compositions can be used to treat various conditions including cancers and inflammation conditions.
Public/Granted literature
- US20140243397A1 CXCR4 INHIBITING CARRIERS FOR NUCLEIC ACID DELIVERY Public/Granted day:2014-08-28
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