Invention Grant
- Patent Title: IRE-1α inhibitors
- Patent Title (中): IRE-1α抑制剂
-
Application No.: US14969837Application Date: 2015-12-15
-
Publication No.: US09546149B2Publication Date: 2017-01-17
- Inventor: John B. Patterson , David G. Lonergan , Gary A. Flynn , Qingpeng Zeng , Peter V. Pallai
- Applicant: MannKind Corporation
- Applicant Address: US CA Valencia
- Assignee: MannKind Corporation
- Current Assignee: MannKind Corporation
- Current Assignee Address: US CA Valencia
- Agency: K&L Gates LLP
- Agent Louis C. Cullman; Brian J. Novak
- Main IPC: C07D213/48
- IPC: C07D213/48 ; C07C65/30 ; A61K31/11 ; C07D333/58 ; C07C47/55 ; C07C47/565 ; C07C47/575 ; C07D213/64 ; C07D213/69 ; C07D213/74 ; C07D217/16 ; C07D231/12 ; C07D239/26 ; C07D239/54 ; C07D261/08 ; C07D277/34 ; C07D295/192 ; C07D307/80 ; C07D317/54 ; C07D319/18 ; C07D321/10 ; C07D333/22 ; C07D417/10 ; A61K31/135 ; A61K31/192 ; A61K31/357 ; A61K31/381 ; A61K31/505 ; A61K31/5375 ; A61K31/5377 ; C07C205/44 ; C07D295/125 ; C07C235/84 ; C07C317/24 ; C07D215/14 ; C07D241/18 ; C07D295/15
Abstract:
Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Public/Granted literature
- US20160168116A1 IRE-1alpha Inhibitors Public/Granted day:2016-06-16
Information query
IPC分类:
