Invention Grant
- Patent Title: Humanized antibodies that bind LGR5
- Patent Title (中): 结合LGR5的人源化抗体
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Application No.: US14677815Application Date: 2015-04-02
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Publication No.: US09546214B2Publication Date: 2017-01-17
- Inventor: Christopher L. Reyes , Peter Chu , Kristen M. Smith , Lioudmila A. Campbell , Farbod Shojaei , John Thomas Norton
- Applicant: Bionomics Inc.
- Applicant Address: US CA San Diego
- Assignee: Bionomics, Inc.
- Current Assignee: Bionomics, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Knobbe, Marens, Olson & Bear LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K16/30 ; A61K45/06 ; A61K39/00
Abstract:
Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.
Public/Granted literature
- US20160031984A1 HUMANIZED ANTIBODIES THAT BIND LGR5 Public/Granted day:2016-02-04
Information query
