Invention Grant
- Patent Title: Conditional replicating cytomegalovirus as a vaccine for CMV
- Patent Title (中): 条件复制巨细胞病毒作为CMV疫苗
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Application No.: US14343637Application Date: 2012-09-04
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Publication No.: US09546355B2Publication Date: 2017-01-17
- Inventor: Tong-Ming Fu , Dai Wang , Muneeswara Babu Medi
- Applicant: Tong-Ming Fu , Dai Wang , Muneeswara Babu Medi
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Henry P. Wu; Gloria M. Fuentes
- International Application: PCT/US2012/053599 WO 20120904
- International Announcement: WO2013/036465 WO 20130314
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to methods of inducing an immune response to cytomegalovirus (CMV) using a genetically modified CMV that is conditionally replication defective. The methods of the invention can be used to treat and/or prevent primary CMV infection, infection due to reactivation of a latent CMV and a super-infection of a different strain of CMV that had been previously encountered. The present invention also relates to a replication defective CMV which has been recombinantly altered to allow for external control of viral replication. Compositions comprising the replication defective CMV are also encompassed by the present invention.
Public/Granted literature
- US20140220062A1 CONDITIONAL REPLICATING CYTOMEGALOVIRUS AS A VACCINE FOR CMV Public/Granted day:2014-08-07
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