Invention Grant
US09549993B2 Specific delivery of toxins conjugated with antibodies to activate matripase
有权
与抗体缀合的毒素的特异性递送以激活matripase
- Patent Title: Specific delivery of toxins conjugated with antibodies to activate matripase
- Patent Title (中): 与抗体缀合的毒素的特异性递送以激活matripase
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Application No.: US14433200Application Date: 2013-10-02
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Publication No.: US09549993B2Publication Date: 2017-01-24
- Inventor: Siang-Yo Lin , Joseph R. Bertino , Chen-Yong Lin , Michael Johnson
- Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , GEORGETOWN UNIVERSITY
- Applicant Address: US NJ New Brunswick US DC Washington
- Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY,GEORGETOWN UNIVERSITY
- Current Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY,GEORGETOWN UNIVERSITY
- Current Assignee Address: US NJ New Brunswick US DC Washington
- Agency: Fox Rothschild LLP
- International Application: PCT/US2013/063090 WO 20131002
- International Announcement: WO2014/055663 WO 20140410
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K16/40 ; A61K31/00 ; A61K31/704 ; A61K31/7048
Abstract:
Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses.
Public/Granted literature
- US20150250895A1 Specific Delivery of Toxins Conjugated with Antiobodies to Activate Matripase Public/Granted day:2015-09-10
Information query
