Invention Grant
- Patent Title: Preparation of Grignard reagents using a fluidized bed
- Patent Title (中): 使用流化床制备格氏试剂
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Application No.: US14899445Application Date: 2014-06-27
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Publication No.: US09550797B2Publication Date: 2017-01-24
- Inventor: Mehul Thathagar , Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Michel Goldbach
- Applicant: DPX Holdings B.V.
- Applicant Address: NL Amsterdam
- Assignee: Patheon Holdings I B.V.
- Current Assignee: Patheon Holdings I B.V.
- Current Assignee Address: NL Amsterdam
- Agency: Pierce Atwood LLP
- Agent Raymond G. Arner
- Priority: EP13173979 20130627
- International Application: PCT/EP2014/063704 WO 20140627
- International Announcement: WO2014/207206 WO 20141231
- Main IPC: C07F3/02
- IPC: C07F3/02 ; C07D257/02 ; C07F15/00 ; C07C29/40 ; C07C67/30
Abstract:
The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.
Public/Granted literature
- US20160137669A1 PREPARATION OF GRIGNARD REAGENTS USING A FLUIDIZED BED Public/Granted day:2016-05-19
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