Invention Grant
- Patent Title: Methods for use of vascular endothelial growth factor antagonists
- Patent Title (中): 血管内皮生长因子拮抗剂的使用方法
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Application No.: US14397435Application Date: 2013-04-26
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Publication No.: US09550818B2Publication Date: 2017-01-24
- Inventor: Donald P. Bottaro , Fabiola Cecchi
- Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Swanson & Bratschun, L.L.C.
- International Application: PCT/US2013/038506 WO 20130426
- International Announcement: WO2013/163606 WO 20131031
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475 ; C07K14/52 ; C07K14/71
Abstract:
The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
Public/Granted literature
- US20150126446A1 VASCULAR ENDOTHELIAL GROWTH FACTOR ANTAGONISTS AND METHODS FOR THEIR USE Public/Granted day:2015-05-07
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