Invention Grant
US09550830B2 Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
有权
在骨髓细胞-1（TREM-1）上表达的结合和阻断触发受体的抗体
- Patent Title: Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
- Patent Title (中): 在骨髓细胞-1（TREM-1）上表达的结合和阻断触发受体的抗体
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Application No.: US13954318Application Date: 2013-07-30
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Publication No.: US09550830B2Publication Date: 2017-01-24
- Inventor: Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
- Applicant: Novo Nordisk A/S
- Applicant Address: US NJ Princeton
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: US NJ Princeton
- Agent Nickki L. Parlet
- Priority: EP12155641 20120215; EP12158974 20120312; EP12176892 20120718
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/28 ; A61K39/00
Abstract:
The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
Public/Granted literature
- US20130309239A1 ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1) Public/Granted day:2013-11-21
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