A system, in certain embodiments, includes a plurality of detachable, three-dimensional diffuser vanes attached to a diffuser plate of a centrifugal compressor. In certain embodiments, the detachable, three-dimensional diffuser vanes may be attached to the diffuser plate using threaded fasteners. In addition, dowel pins may be used to align the detachable, three-dimensional diffuser vanes with respect to the diffuser plate. However, in other embodiments, the detachable, three-dimensional diffuser vanes may include a tab configured to fit securely within a groove in the diffuser plate. In addition, the tabs of the detachable, three-dimensional diffuser vanes may include indentions that mate with extensions extending from the diffuser plate, wherein the tabs may slide into slots between the extensions and the grooves of the diffuser plate.