Invention Grant
US09551711B2 Compositions and methods for detecting nitration of PKG-1α and methods of use thereof
有权
用于检测PKG-1α硝化的组合物和方法及其使用方法
- Patent Title: Compositions and methods for detecting nitration of PKG-1α and methods of use thereof
- Patent Title (中): 用于检测PKG-1α硝化的组合物和方法及其使用方法
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Application No.: US14502160Application Date: 2014-09-30
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Publication No.: US09551711B2Publication Date: 2017-01-24
- Inventor: Stephen M. Black
- Applicant: Augusta University Research Institute, Inc.
- Applicant Address: US GA Augusta
- Assignee: Augusta University Research Institute, Inc.
- Current Assignee: Augusta University Research Institute, Inc.
- Current Assignee Address: US GA Augusta
- Agency: Smith Gambrell & Russell LLP
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G01N33/53 ; G01N33/573 ; C07K16/40 ; C07K16/44
Abstract:
Antibodies for detecting nitration of nitrotyrosine 247 PKG-1α and antibodies for detecting nitrotyrosine 425 of PKG-1α are disclosed. Methods of detecting nitrotyrosine 247 PKG-1α and nitrotyrosine 425 of PKG-1α, and uses thereof are also disclosed for identification and diagnosis or phenotypes, pathologies, diseases and disorders associated with protein nitration of PKG-1α are also disclosed. In a preferred embodiment, one or more of the disclosed antibodies is used in the disclosed methods.
Public/Granted literature
- US20150093759A1 COMPOSITIONS AND METHODS FOR DETECTING NITRATION OF PKG-1a AND METHODS OF USE THEREOF Public/Granted day:2015-04-02
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