Invention Grant
- Patent Title: Methods of therapeutic monitoring of phenylacetic acid prodrugs
- Patent Title (中): 苯乙酸前药的治疗监测方法
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Application No.: US13610580Application Date: 2012-09-11
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Publication No.: US09561197B2Publication Date: 2017-02-07
- Inventor: Bruce Scharschmidt , Masoud Mokhtarani
- Applicant: Bruce Scharschmidt , Masoud Mokhtarani
- Applicant Address: US IL Lake Forest
- Assignee: Horizon Therapeutics, LLC
- Current Assignee: Horizon Therapeutics, LLC
- Current Assignee Address: US IL Lake Forest
- Main IPC: A61K31/192
- IPC: A61K31/192 ; A61K31/216 ; A61K31/225 ; G01N33/68
Abstract:
The present disclosure provides methods for adjusting the dosage of PAA prodrugs (e.g., HPN-100, PBA) based on measurement of PAA and PAGN in plasma and calculating the PAA:PAGN ratio so as to determine whether PAA to PAGN conversion is saturated.
Public/Granted literature
- US20130281530A1 METHODS OF THERAPEUTIC MONITORING OF PHENYLACETIC ACID PRODRUGS Public/Granted day:2013-10-24
Information query
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