Invention Grant
US09561230B2 Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
有权
芳基取代的三环磺酰胺作为甲硫氨酰氨基肽酶2调节剂
- Patent Title: Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
- Patent Title (中): 芳基取代的三环磺酰胺作为甲硫氨酰氨基肽酶2调节剂
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Application No.: US14878428Application Date: 2015-10-08
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Publication No.: US09561230B2Publication Date: 2017-02-07
- Inventor: Susan Mary Cramp , Hazel Joan Dyke , Thomas David Pallin , Robert Zahler
- Applicant: Zafgen, Inc.
- Applicant Address: US MA Boston
- Assignee: Zafgen, Inc.
- Current Assignee: Zafgen, Inc.
- Current Assignee Address: US MA Boston
- Agency: Goodwin Procter LLP
- Main IPC: C07C317/14
- IPC: C07C317/14 ; A61K31/5383 ; A61K9/00 ; A61K31/407 ; A61K31/4745 ; A61K31/4188
Abstract:
The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X and n are as defined herein.
Public/Granted literature
- US20160256469A1 TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME Public/Granted day:2016-09-08
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