Invention Grant
- Patent Title: LLP2A-bisphosphonate conjugates for osteoporosis treatment
- Patent Title (中): 用于骨质疏松症治疗的LLP2A-双膦酸盐共轭物
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Application No.: US14806398Application Date: 2015-07-22
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Publication No.: US09561256B2Publication Date: 2017-02-07
- Inventor: Kit S. Lam , Ruiwu Liu , Wei Yao , Nancy Lane
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P19/08 ; A61P19/02 ; A61P19/10 ; A61K38/10 ; A61K38/16 ; A61K38/08 ; A61K38/06 ; A61K38/07 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61K31/663 ; C07K7/06 ; A61K31/66 ; C07F9/02 ; A61K31/00 ; A61K31/661 ; A61K47/48 ; C07K5/09 ; C07K5/103 ; C07K5/107 ; C07K5/11 ; A61K35/28
Abstract:
The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone.
Public/Granted literature
- US20160074461A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT Public/Granted day:2016-03-17
Information query
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