Invention Grant
US09561264B2 Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
有权
编码染色体7p15-21多药耐药性人P-糖蛋白同源物的基因及其用途
- Patent Title: Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
- Patent Title (中): 编码染色体7p15-21多药耐药性人P-糖蛋白同源物的基因及其用途
-
Application No.: US13938938Application Date: 2013-07-10
-
Publication No.: US09561264B2Publication Date: 2017-02-07
- Inventor: Markus H. Frank , Mohamed H. Sayegh
- Applicant: The Brigham and Women's Hospital, Inc.
- Applicant Address: US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K39/00 ; A61K39/395 ; C07K16/28 ; C07K14/705 ; A61K38/00 ; A61K48/00
Abstract:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Public/Granted literature
Information query
IPC分类:
