Invention Grant
- Patent Title: Target peptides for immunotherapy and diagnostics
- Patent Title (中): 用于免疫治疗和诊断的靶肽
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Application No.: US14424702Application Date: 2013-09-03
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Publication No.: US09561266B2Publication Date: 2017-02-07
- Inventor: Donald F. Hunt , Jeffrey Shabanowitz , Stacy A. Malaker , Victor H. Engelhard , Angela Zarling , Kara L. Cummings , Rebecca C. Obeng , Mark Cobbold
- Applicant: U.Va. Licensing & Ventures Group , The University of Birmingham
- Applicant Address: US VA Charlottesville GB Birmingham
- Assignee: University of Virginia Patent Foundation,The University of Birmingham
- Current Assignee: University of Virginia Patent Foundation,The University of Birmingham
- Current Assignee Address: US VA Charlottesville GB Birmingham
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- International Application: PCT/US2013/057856 WO 20130903
- International Announcement: WO2014/036562 WO 20140306
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K39/00 ; A61K35/15 ; A61K35/17 ; A61K45/06 ; C07K16/28 ; G01N33/574 ; G01N33/68

Abstract:
A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
Public/Granted literature
- US20150224182A1 TARGET PEPTIDES FOR IMMUNOTHERAPY AND DIAGNOSTICS Public/Granted day:2015-08-13
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