Invention Grant
US09561284B2 Pharmaceutical composition containing a block copolymer bound to a boronic acid compound
有权
含有与硼酸化合物结合的嵌段共聚物的药物组合物
- Patent Title: Pharmaceutical composition containing a block copolymer bound to a boronic acid compound
- Patent Title (中): 含有与硼酸化合物结合的嵌段共聚物的药物组合物
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Application No.: US14008181Application Date: 2012-04-02
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Publication No.: US09561284B2Publication Date: 2017-02-07
- Inventor: Hiroyuki Saito , Katsutoshi Kobayashi , Ryosuke Tanaka , Mitsunori Harada , Yasuki Kato
- Applicant: Hiroyuki Saito , Katsutoshi Kobayashi , Ryosuke Tanaka , Mitsunori Harada , Yasuki Kato
- Applicant Address: JP Kashiwa-shi
- Assignee: NANOCARRIER CO., LTD.
- Current Assignee: NANOCARRIER CO., LTD.
- Current Assignee Address: JP Kashiwa-shi
- Agency: J-Tek Law PLLC
- Agent Jeffrey Tekanic; Scott Wakeman
- Priority: JP2011-080509 20110331
- International Application: PCT/JP2012/058831 WO 20120402
- International Announcement: WO2012/133884 WO 20121004
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K31/69

Abstract:
A pharmaceutical composition includes a block copolymer having a hydrophilic segment, a hydrophobic segment, and a boronic acid compound bound to a side chain of the hydrophobic segment via a linker moiety that includes a heterocyclic structure. The heterocyclic structure contains a cyclic skeleton that includes a boron atom of the boronic acid compound, one or two atom(s) X bound to the boron atom and selected from an oxygen atom and a nitrogen atom, and one or two carbon atom(s) (respectively) bound to the atom(s) X. The block copolymer further includes at least one organic group bound to the carbon atom(s). The organic group(s) contain(s) an aromatic group or cyclic alkyl group that sterically protects a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atom(s) X.
Public/Granted literature
- US20140017192A1 PHARMACEUTICAL COMPOSITION CONTAINING BLOCK COPOLYMER COMPRISING BORIC ACID COMPOUND Public/Granted day:2014-01-16
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