Invention Grant
- Patent Title: Carrier-linked carbamate prodrug linkers
- Patent Title (中): 载体连接的氨基甲酸酯前药接头
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Application No.: US13574120Application Date: 2011-01-21
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Publication No.: US09561285B2Publication Date: 2017-02-07
- Inventor: Harald Rau , Torben Lessmann
- Applicant: Harald Rau , Torben Lessmann
- Applicant Address: DK Hellerup
- Assignee: Ascendis Pharma AS
- Current Assignee: Ascendis Pharma AS
- Current Assignee Address: DK Hellerup
- Agency: Frommer Lawrence Haug LLP
- Priority: EP10151470 20100122
- International Application: PCT/EP2011/050819 WO 20110121
- International Announcement: WO2011/089214 WO 20110728
- Main IPC: A61K47/48
- IPC: A61K47/48

Abstract:
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
Public/Granted literature
- US20130035635A1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS Public/Granted day:2013-02-07
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