Invention Grant
US09561285B2 Carrier-linked carbamate prodrug linkers 有权
载体连接的氨基甲酸酯前药接头

Carrier-linked carbamate prodrug linkers
Abstract:
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
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