Disclosed is a charged hollow fiber membrane having hexagonal voids for use in high throughput applications. The membrane includes: (i) an inner surface; (ii) an outer surface; (iii) a porous bulk disposed therebetween, wherein the porous bulk comprises at least a first region including: a) a first set of pores having a controlled pore size and having outer rims; b) a second set of pores connecting the outer rims of the first set of pores, wherein the pore size of the first set of pores is greater than the pore size of the second set of pores; and c) a polymer matrix supporting the first set of pores; and (iv) at least one charged zone disposed on the inner surface, on the outer surface, and/or in the porous bulk hollow fiber membrane. Also disclosed is a method for preparing such hollow fiber membranes, which involves coating a filament with a coating composition that includes a membrane-forming polymer, a charged polymer, and dissolvable nanoparticles, followed by phase invention, dissolving of the nanoparticles, and removal of the filament.