A greeting card tissue box cover is provided. In one embodiment, the greeting card body is arranged in a single plane, having first, second, third, and fourth panels that are foldable along multiple fold lines to arrange the greeting card body into a plurality of folded positions. In a first, collapsed position, the greeting card is folded such that each of the multiple panels is parallel to a single plane, thereby enabling mailing of the folded greeting card. In a second, expanded position, the once-collapsed greeting card is configured such that the first, second, third, and fourth panels contour to the exterior of a tissue box, providing a cover thereto. At least two flaps of the greeting card body adjoin a top surface of the tissue box while permitting access to the contents of the tissue box.