Invention Grant
US09562014B2 (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
有权
（+） - 吗啡喃作为toll样受体9的拮抗剂及其治疗用途
- Patent Title: (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
- Patent Title (中): （+） - 吗啡喃作为toll样受体9的拮抗剂及其治疗用途
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Application No.: US12975407Application Date: 2010-12-22
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Publication No.: US09562014B2Publication Date: 2017-02-07
- Inventor: Bobby N. Trawick , David W. Berberich , Christopher W. Grote
- Applicant: Bobby N. Trawick , David W. Berberich , Christopher W. Grote
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt LLC
- Current Assignee: Mallinckrodt LLC
- Current Assignee Address: US MO Hazelwood
- Main IPC: A61K31/485
- IPC: A61K31/485 ; C07D489/08 ; C07D217/20 ; A61K31/472 ; C07D489/02 ; C07D489/00 ; A61P29/00 ; A61P25/04 ; A61K31/167 ; C07D221/28 ; C07D489/10
Abstract:
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
Public/Granted literature
- US20110136845A1 (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof Public/Granted day:2011-06-09
Information query
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