Invention Grant
US09562015B2 Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations
有权
用于增强药物递送至眼睛和延长递送配方的方法和组合物
- Patent Title: Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations
- Patent Title (中): 用于增强药物递送至眼睛和延长递送配方的方法和组合物
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Application No.: US14359146Application Date: 2012-11-16
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Publication No.: US09562015B2Publication Date: 2017-02-07
- Inventor: Uday B. Kompella , Ashish Thakur
- Applicant: The Regents of the University of Colorado
- Applicant Address: US CO Denver
- Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY
- Current Assignee Address: US CO Denver
- Agency: Fisherbroyles, LLP
- Agent Jason M. Pass
- International Application: PCT/US2012/065620 WO 20121116
- International Announcement: WO2013/074988 WO 20130523
- Main IPC: C07D213/12
- IPC: C07D213/12 ; A61K31/415 ; C07D231/12 ; C07D498/22 ; A61K31/58
Abstract:
The present invention comprises compounds and compositions thereof for enhanced drug delivery. Pro-drug and double pro-drug derivatives of corticosteroids non-steroid anti-inflammatory drugs (NSAIDs), and ruboxistaurin for delivery to the eye are provided. The compounds and compositions are useful for treating various ocular diseases, including ocular diseases effecting the posterior segments of the eye. In addition, the present invention is directed to particle in particle carrier formulations for sustained release of therapeutic agents.
Public/Granted literature
- US20140309200A1 Methods and Compositions for Enhanced Drug Delivery to the Eye and Extended Delivery Formulations Public/Granted day:2014-10-16
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