Invention Grant
- Patent Title: Substituted pyridazines as EGFR and/or KRAS inhibitors
- Patent Title (中): 取代的哒嗪作为EGFR和/或KRAS抑制剂
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Application No.: US12520256Application Date: 2007-12-21
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Publication No.: US09562019B2Publication Date: 2017-02-07
- Inventor: Hakim Djaballah , Harold E. Varmus , David Shum , Romel Somwar , Alexander Chucholowski , Mohan Santhanam Thiruvazhi
- Applicant: Hakim Djaballah , Harold E. Varmus , David Shum , Romel Somwar , Alexander Chucholowski , Mohan Santhanam Thiruvazhi
- Applicant Address: US NY New York
- Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee Address: US NY New York
- Agency: Choate, Hall, and Stewart LLP
- Agent Brenda Herschbach Jarrell
- International Application: PCT/US2007/088543 WO 20071221
- International Announcement: WO2008/080056 WO 20080703
- Main IPC: C07D237/10
- IPC: C07D237/10 ; C07D237/04 ; C07D307/68 ; C07D307/71 ; C07D307/85 ; C07D307/92 ; C07D401/04 ; C07D403/04 ; C07D403/12 ; C07D405/04 ; C07D405/06 ; C07D405/12 ; C07D405/14 ; C07D409/14 ; C07D471/04 ; C07D495/04 ; C07D401/14 ; C07D405/10 ; C07D413/04 ; C07D417/10
Abstract:
The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
Public/Granted literature
- US20130131062A1 PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS Public/Granted day:2013-05-23
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