Invention Grant
- Patent Title: 2-acylaminothiazole derivative or salt thereof
- Patent Title (中): 2-酰基氨基噻唑衍生物或其盐
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Application No.: US14770648Application Date: 2014-02-27
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Publication No.: US09562044B2Publication Date: 2017-02-07
- Inventor: Taisuke Takahashi , Jun Maeda , Yusuke Inagaki , Kenji Negoro , Hiroaki Tanaka , Kazuhiro Yokoyama , Hajime Takamatsu , Takanori Koike , Issei Tsukamoto
- Applicant: ASTELLAS PHARMA INC.
- Applicant Address: JP Chuo-ku
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Chuo-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2013-039964 20130228
- International Application: PCT/JP2014/054803 WO 20140227
- International Announcement: WO2014/133056 WO 20140904
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D491/08 ; A61K31/497 ; A61K31/5377 ; C07D491/107

Abstract:
Thiazole derivatives having pyrazine-2-carbonylamino substituted at the 2-position of the following formula (I): are excellent muscarinic M3 receptor positive allosteric modulators, and are useful for treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor. The 2-acylaminothiazole derivatives and salts thereof can be used for treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, for example, voiding dysfunctions such as underactive bladder.
Public/Granted literature
- US20160002218A1 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF Public/Granted day:2016-01-07
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