Invention Grant
- Patent Title: Oral therapy of necrotizing enterocolitis
- Patent Title (中): 坏死性小肠结肠炎的口服治疗
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Application No.: US14036960Application Date: 2013-09-25
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Publication No.: US09562066B2Publication Date: 2017-02-07
- Inventor: David J. Hackam
- Applicant: University of Pittsburgh—of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts, LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C12N15/117 ; C07H21/04 ; A61K45/06 ; A61K31/711
Abstract:
The present invention relates to methods of treating or reducing the risk of necrotizing enterocolitis (NEC) in an infant comprising orally administering an effective amount of a CpG-ODN. It is based, at least in part, on the results of experiments in which orally administered CpG-ODNs were observed to reduce the histopathology and markers of inflammation in a murine model for NEC. The present invention further provides for oral formulations of CpG-ODN for administration to infants.
Public/Granted literature
- US20140086982A1 ORAL THERAPY OF NECROTIZING ENTEROCOLITIS Public/Granted day:2014-03-27
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