Invention Grant
US09562067B2 Process for the production of 19-norpregn-4-en-3,20-dione-17α-ol(gestonorone) and intermediates therefor
有权
生产19-去甲孕-4-烯-3,20-二酮-17α-醇（孕酮）及其中间体的方法
- Patent Title: Process for the production of 19-norpregn-4-en-3,20-dione-17α-ol(gestonorone) and intermediates therefor
- Patent Title (中): 生产19-去甲孕-4-烯-3,20-二酮-17α-醇（孕酮）及其中间体的方法
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Application No.: US15038299Application Date: 2014-12-15
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Publication No.: US09562067B2Publication Date: 2017-02-07
- Inventor: János Csörgei , Anita Horváth , Csaba Sánta , Sándor Mahó , Zoltán Béni , János Horváth
- Applicant: RICHTER GEDEON NYRT.
- Applicant Address: HU Budapest
- Assignee: RICHTER GEDEON NYRT.
- Current Assignee: RICHTER GEDEON NYRT.
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: HU1300722 20131216
- International Application: PCT/IB2014/066907 WO 20141215
- International Announcement: WO2015/092647 WO 20150625
- Main IPC: C07J7/00
- IPC: C07J7/00 ; C07J41/00 ; C07C51/00 ; C07J1/00 ; C07J51/00
Abstract:
The present invention relates to a new stereoselective process for the synthesis of 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
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