Invention Grant
US09562068B2 Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
有权
用于制备7α-（甲氧基羰基）-3-OXO-17α-孕-4,9（11） - 二烯-17,17-碳内酯的方法，该药物用于合成具有药理学活性的分子
- Patent Title: Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
- Patent Title (中): 用于制备7α-（甲氧基羰基）-3-OXO-17α-孕-4,9（11） - 二烯-17,17-碳内酯的方法，该药物用于合成具有药理学活性的分子
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Application No.: US14885861Application Date: 2015-10-16
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Publication No.: US09562068B2Publication Date: 2017-02-07
- Inventor: Roberto Lenna , Riccardo Di Brisco , Francesco Barbieri
- Applicant: INDUSTRIALE CHIMICA S.R.L.
- Applicant Address: IT
- Assignee: INDUSTRIALE CHIMICA, S.r.l.
- Current Assignee: INDUSTRIALE CHIMICA, S.r.l.
- Current Assignee Address: IT
- Agency: Fish & Tsang, LLP
- Priority: ITMI2014A1800 20141017
- Main IPC: C07J21/00
- IPC: C07J21/00
Abstract:
An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. Intermediate (V) is a key molecule for the synthesis of eplerenone, a synthetic steroid with pharmacological activity used in the treatment of chronic pathological conditions, including hypertension.
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