Invention Grant
- Patent Title: Selective caspase inhibitors and uses thereof
- Patent Title (中): 选择性胱天蛋白酶抑制剂及其用途
-
Application No.: US14307025Application Date: 2014-06-17
-
Publication No.: US09562069B2Publication Date: 2017-02-07
- Inventor: Jan-Eric Ahlfors , Khalid Mekouar
- Applicant: Genesis Technologies Limited
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: C07K5/08
- IPC: C07K5/08 ; C07K5/10 ; C07K5/062 ; C07C271/22 ; C07C317/50 ; C07D209/16 ; C07D213/81 ; C07D215/12 ; C07D295/26 ; C07F9/40 ; C07F9/6533 ; C07K5/02 ; C07K5/087 ; C07K5/093 ; C07K14/81 ; C07K5/083 ; C07K5/103 ; A61K38/00 ; C07K5/065 ; C07K5/072 ; C07K5/078
Abstract:
The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).
Public/Granted literature
- US20150011458A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF Public/Granted day:2015-01-08
Information query
