Invention Grant
US09562073B2 Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
有权
Matriptase和u-纤溶酶原激活物底物和其他可裂解部分及其使用方法
- Patent Title: Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
- Patent Title (中): Matriptase和u-纤溶酶原激活物底物和其他可裂解部分及其使用方法
-
Application No.: US14610468Application Date: 2015-01-30
-
Publication No.: US09562073B2Publication Date: 2017-02-07
- Inventor: Stephen James Moore , Margaret Thy Luu Nguyen , Daniel R. Hostetter , Olga Vasiljeva
- Applicant: CytomX Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: CYTOMX THERAPEUTICS, INC.
- Current Assignee: CYTOMX THERAPEUTICS, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Cooley LLP
- Agent Ivor R. Elrifi
- Main IPC: C07K7/06
- IPC: C07K7/06 ; C07K7/08 ; A61K47/48 ; C07K16/00 ; C07K16/22 ; C07K16/40 ; A61K39/00
Abstract:
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
Public/Granted literature
Information query
