Invention Grant
- Patent Title: Methods for identifying broadly neutralizing antibodies utilizing recombinant HIV-1 envelope glycoproteins comprising stabilizing mutations
- Patent Title (中): 使用包含稳定突变的重组HIV-1包膜糖蛋白鉴定广泛中和抗体的方法
-
Application No.: US13928561Application Date: 2013-06-27
-
Publication No.: US09562078B2Publication Date: 2017-02-07
- Inventor: Simon Hoffenberg , Christopher L. Parks , Alexei Carpov
- Applicant: International AIDS Vaccine Initiative
- Applicant Address: US NY New York
- Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
- Current Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
- Current Assignee Address: US NY New York
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Main IPC: A61K39/21
- IPC: A61K39/21 ; G01N33/53 ; C12N7/00 ; C07K14/005 ; A61K39/12 ; A61K39/00
Abstract:
The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
Public/Granted literature
- US20140037681A1 HIV-1 ENVELOPE GLYCOPROTEIN Public/Granted day:2014-02-06
Information query
