Invention Grant
US09562223B2 Methods for reducing intraocular pressure by administering a soluble hyaluronidase glycoprotein (sHASEGP)
有权
通过施用可溶性透明质酸糖蛋白（sHASEGP）降低眼内压的方法
- Patent Title: Methods for reducing intraocular pressure by administering a soluble hyaluronidase glycoprotein (sHASEGP)
- Patent Title (中): 通过施用可溶性透明质酸糖蛋白（sHASEGP）降低眼内压的方法
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Application No.: US13999454Application Date: 2014-02-26
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Publication No.: US09562223B2Publication Date: 2017-02-07
- Inventor: Louis Bookbinder , Anirban Kundu , Gregory I. Frost
- Applicant: HALOZYME, INC.
- Applicant Address: US CA San Diego
- Assignee: Halozyme, Inc.
- Current Assignee: Halozyme, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Dentons US LLP
- Agent Stephanie Seidman
- Main IPC: A61K38/47
- IPC: A61K38/47 ; A61K9/00 ; A61K47/48 ; C12N9/26
Abstract:
Provided are methods for reducing intraocular pressure in the eye of a subject by administering neutral active soluble active hyaluronidase glycoproteins (sHASEGPs) and modified forms thereof to the eye. The sHASEGPs are soluble forms of human PH20 hyaluronidase. Also provided are the sHASEGPs, methods of manufacture, and uses thereof. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described. The sHASEGPs include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain.
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