Invention Grant
- Patent Title: Transferrin/transferrin receptor-mediated siRNA delivery
- Patent Title (中): 转铁蛋白/转铁蛋白受体介导的siRNA递送
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Application No.: US14801161Application Date: 2015-07-16
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Publication No.: US09562230B2Publication Date: 2017-02-07
- Inventor: Jon E. Chatterton , Abbot F. Clark
- Applicant: Arrowhead Research Corporation
- Applicant Address: US CA Pasadena
- Assignee: Arrowhead Pharmaceuticals, Inc.
- Current Assignee: Arrowhead Pharmaceuticals, Inc.
- Current Assignee Address: US CA Pasadena
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K9/00 ; A61K47/48 ; C12N15/87 ; A61K31/7088
Abstract:
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided.
Public/Granted literature
- US20150315592A1 TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY Public/Granted day:2015-11-05
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