Invention Grant
- Patent Title: Therapeutic agent for corneal epithelial disorder
- Patent Title (中): 角膜上皮病的治疗剂
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Application No.: US14914962Application Date: 2014-08-27
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Publication No.: US09562231B2Publication Date: 2017-02-07
- Inventor: Ayumi Nakagawa , Takeshi Nakajima , Mitsuyoshi Azuma
- Applicant: SENJU PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Osaka-shi
- Assignee: Senju Pharmaceutical Co., Ltd.
- Current Assignee: Senju Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka-shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2013-176996 20130828
- International Application: PCT/JP2014/072484 WO 20140827
- International Announcement: WO2015/030078 WO 20150305
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/11 ; A61K48/00 ; C12N15/113 ; C12N5/079

Abstract:
A therapeutic agent for a corneal epithelial disorder, containing a miR-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells, containing a miR-203 inhibitor; a liquid culture medium for use in the manufacture of a corneal epithelial sheet, containing a miR-203 inhibitor; and a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using a liquid culture medium containing a miR-203 inhibitor. According to the present invention, a therapeutic agent for a corneal epithelial disorder, an agent for promoting proliferation of corneal epithelial cells, a liquid culture medium for use in the manufacture of a corneal epithelial sheet, a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using the liquid culture medium, and a method for treating a corneal epithelial disorder can be provided. The present inventors have also found that not only the above effects are exhibited by inhibiting miRNA richly contained in tears, but also the agent specifically acts on eye surfaces, so that the present invention can be expected to show high safety.
Public/Granted literature
- US20160208250A1 THERAPEUTIC AGENT FOR CORNEAL EPITHELIAL DISORDER Public/Granted day:2016-07-21
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