Invention Grant
- Patent Title: Screening method for therapeutic agent for chondropathy and modified chondrocyte for treatment of chondropathy
- Patent Title (中): 软骨病治疗剂和软骨细胞治疗软骨病的筛选方法
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Application No.: US14118971Application Date: 2012-05-29
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Publication No.: US09562272B2Publication Date: 2017-02-07
- Inventor: Noriyuki Tsumaki , Hiroshi Takemori
- Applicant: Noriyuki Tsumaki , Hiroshi Takemori
- Applicant Address: JP Kyoto
- Assignee: KYOTO UNIVERSITY
- Current Assignee: KYOTO UNIVERSITY
- Current Assignee Address: JP Kyoto
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2011-121788 20110531
- International Application: PCT/JP2012/063709 WO 20120529
- International Announcement: WO2012/165407 WO 20121206
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N33/483 ; G01N33/487 ; G01N33/50 ; G01N33/53 ; G01N33/68 ; C12Q1/68 ; C12N5/077 ; C12Q1/48
Abstract:
The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and/or a disease associated with impaired cartilage growth.
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