A real-time threat detection system incorporating a plurality of sensors adapted to detect radiation across the majority of the electromagnetic spectrum. The system also includes an aided or automatic target recognition module which compares the data from the sensors against known radiation signatures and issues an alert when an anomalous signature is detected. The system further includes an operator station which displays sensor information allowing the operator to intervene. The sensors detect radiation which is normally emitted by persons or other bodies and display areas to the operator where normal emissions are blocked.