Invention Grant
US09567279B2 Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
有权
在非α-生育三烯酚存在下氧化α-生育三烯酚的方法
- Patent Title: Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
- Patent Title (中): 在非α-生育三烯酚存在下氧化α-生育三烯酚的方法
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Application No.: US14850855Application Date: 2015-09-10
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Publication No.: US09567279B2Publication Date: 2017-02-14
- Inventor: Paul Mollard
- Applicant: Edison Pharmaceuticals, Inc.
- Applicant Address: US CA Mountain View
- Assignee: Edison Pharmaceuticals, Inc.
- Current Assignee: Edison Pharmaceuticals, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: Squire Patton Boggs (US) LLP
- Main IPC: C07C46/00
- IPC: C07C46/00 ; C07C403/00 ; C07D311/00 ; C07C46/06 ; C07D311/72 ; C07C403/08
Abstract:
A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-to-cotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.
Public/Granted literature
- US20160002138A1 METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS Public/Granted day:2016-01-07
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