Invention Grant
US09567301B2 Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
有权
可用作myc抑制剂的吡咯-1-基苯甲酸衍生物
- Patent Title: Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
- Patent Title (中): 可用作myc抑制剂的吡咯-1-基苯甲酸衍生物
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Application No.: US14440200Application Date: 2013-11-01
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Publication No.: US09567301B2Publication Date: 2017-02-14
- Inventor: James E. Bradner , Michael R. McKeown , Peter B. Rahl , Richard A. Young , Jason J. Marineau
- Applicant: Whitehead Institute for Biomedical Research , Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston US MA Cambridge
- Assignee: Dana-Farber Cancer Institute, Inc.,Whitehead Institute for Biomedical Research
- Current Assignee: Dana-Farber Cancer Institute, Inc.,Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Boston US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2013/068159 WO 20131101
- International Announcement: WO2014/071247 WO 20140508
- Main IPC: C07D207/327
- IPC: C07D207/327 ; C07D401/12 ; C07D207/27 ; C07D209/04 ; C07D403/06 ; C07D409/04 ; C07D413/12 ; C07D417/06
Abstract:
The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.
Public/Granted literature
- US09540320B2 Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors Public/Granted day:2017-01-10
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