Invention Grant
US09567384B2 Phosphorylation on the Thr-248 and/or Thr-250 residues of transcription factor E2F4 as a therapeutic target in pathological processes associated with somatic polyploidy
有权
转录因子E2F4的Thr-248和/或Thr-250残基上的磷酸化作为与体细胞多倍体相关的病理过程中的治疗靶标
- Patent Title: Phosphorylation on the Thr-248 and/or Thr-250 residues of transcription factor E2F4 as a therapeutic target in pathological processes associated with somatic polyploidy
- Patent Title (中): 转录因子E2F4的Thr-248和/或Thr-250残基上的磷酸化作为与体细胞多倍体相关的病理过程中的治疗靶标
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Application No.: US14352584Application Date: 2012-11-15
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Publication No.: US09567384B2Publication Date: 2017-02-14
- Inventor: Jose Maria Frade Lopez
- Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
- Applicant Address: ES Madrid
- Assignee: Consejo Superior de Investigaciones Cientificas (CSIC)
- Current Assignee: Consejo Superior de Investigaciones Cientificas (CSIC)
- Current Assignee Address: ES Madrid
- Agency: Kramer Amado P.C.
- Priority: ES201131892 20111124
- International Application: PCT/ES2012/070795 WO 20121115
- International Announcement: WO2013/076331 WO 20130530
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/16 ; A61P3/04 ; A61P25/00 ; A61P25/28 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; C07K14/47 ; A61K38/17
Abstract:
The object of the invention is based on inhibiting specific phosphorylation on Thr248 and/or Thr250 residues of human transcription factor E2F4 to inhibit somatic endoreduplication processes in postmitotic cells which may be associated with various pathological conditions. The invention covers all currently known methods for the specific inhibition of protein phosphorylation (including the expression of mutant forms of E2F4 without Thr residues phosphorylated by p38MAPK) or methods developed in the future that may be applied to Thr-248 and/or Thr-250 residues of human transcription factor E2F4.
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