Invention Grant
- Patent Title: Regulators of NFAT and/or store-operated calcium entry
- Patent Title (中): NFAT的调节剂和/或储存操作的钙进入
-
Application No.: US13877472Application Date: 2011-10-10
-
Publication No.: US09567580B2Publication Date: 2017-02-14
- Inventor: Anjana Rao , Patrick Hogan , Sonia Sharma
- Applicant: Anjana Rao , Patrick Hogan , Sonia Sharma
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Tari W. Mills
- International Application: PCT/US2011/055561 WO 20111010
- International Announcement: WO2012/048316 WO 20120412
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K48/00
Abstract:
Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.
Public/Granted literature
- US20140093542A1 REGULATORS OF NFAT AND/OR STORE-OPERATED CALCIUM ENTRY Public/Granted day:2014-04-03
Information query
IPC分类:
