Invention Grant
US09567585B2 Antisense oligonucleotide modulators of serotonin receptor 2C and uses thereof
有权
5-羟色胺受体2C的反义寡核苷酸调节剂及其用途
- Patent Title: Antisense oligonucleotide modulators of serotonin receptor 2C and uses thereof
- Patent Title (中): 5-羟色胺受体2C的反义寡核苷酸调节剂及其用途
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Application No.: US14357388Application Date: 2012-11-09
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Publication No.: US09567585B2Publication Date: 2017-02-14
- Inventor: Stefan Stamm , Manli Shen , Serene Josiah
- Applicant: Shire Human Genetic Therapies, Inc. , University of Kentucky
- Applicant Address: US MA Lexington US KY Lexington
- Assignee: Shire Human Genetic Therapies, Inc.,University of Kentucky
- Current Assignee: Shire Human Genetic Therapies, Inc.,University of Kentucky
- Current Assignee Address: US MA Lexington US KY Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen
- International Application: PCT/US2012/064319 WO 20121109
- International Announcement: WO2013/071022 WO 20130516
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113
Abstract:
The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders or conditions based on such modulators. In particular, oligonucleotides modulators according to the invention target specific regions in the Exon V/Intron V junction of the human HTR2C pre-mRNA and drive expression of HTR2C Vb splice isoform, leading to increased generation of non-edited strong HTR2C receptor and enhanced serotonin receptor activity.
Public/Granted literature
- US20140275222A1 ANTISENSE OLIGONUCLEOTIDE MODULATORS OF SEROTONIN RECEPTOR 2C AND USES THEREOF Public/Granted day:2014-09-18
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