Mechanisms for spatially isolating a region of interest (ROI) in a scene are disclosed. A first sensor generates sensor data that quantifies energy received from a scene within a field of view (FOV) of the first sensor to generate a real-time FOV full motion video. A processor analyzes the sensor data to identify a first ROI during a wait period of a frame period of the first sensor. A first subset of micromirrors in a micromirror array that is directed toward the scene is identified. The first subset of micromirrors receives energy from the first ROI. At least one micromirror in the first subset is controlled to move from a primary position of the at least one micromirror to a first tilt position of the at least one micromirror to reflect the energy from the first ROI toward a second sensor, the first ROI being spatially isolated from the real-time FOV full motion video.