Mechanisms are provided for accelerated data deduplication. A data stream is received an input interface and maintained in memory. Chunk boundaries are detected and chunk fingerprints are calculated using a deduplication accelerator while a processor maintains a state machine. A deduplication dictionary is accessed using a chunk fingerprint to determine if the associated data chunk has previously been written to persistent memory. If the data chunk has previously been written, reference counts may be updated but the data chunk need not be stored again. Otherwise, datastore suitcases, filemaps, and the deduplication dictionary may be updated to reflect storage of the data chunk. Direct memory access (DMA) addresses are provided to directly transfer a chunk to an output interface as needed.