Data compression using a combination of content independent data compression and content dependent data compression. In one aspect, a system for compressing data comprises: a processor, and a plurality of data compression encoders wherein at least one data encoder utilizes asymmetric data compression. The processor is configured to determine one or more parameters, attributes, or values of the data within at least a portion of a data block containing either video or audio data, to select one or more data compression encoders from the plurality of data compression encoders based upon the determined one or more parameters, attributes, or values of the data and a throughput of a communications channel, and to perform data compression with the selected one or more data compression encoders on at least the portion of the data block.