Invention Grant
US09572909B2 Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
有权
用于神经再生的电极神经导管设计用于调节神经结构
- Patent Title: Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
- Patent Title (中): 用于神经再生的电极神经导管设计用于调节神经结构
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Application No.: US13394415Application Date: 2010-09-14
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Publication No.: US09572909B2Publication Date: 2017-02-21
- Inventor: David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
- Applicant: David Simpson , Gary Bowlin , Raymond Colello , Woon Chow , Balendu Shekhar Jha
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: Whitham, Curtis & Cook, P.C.
- International Application: PCT/US2010/048744 WO 20100914
- International Announcement: WO2011/032139 WO 20110317
- Main IPC: A61L27/18
- IPC: A61L27/18 ; A61F2/02 ; A61B17/11
Abstract:
Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
Public/Granted literature
- US20120221025A1 ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE Public/Granted day:2012-08-30
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