A device, system and method for self-administration of a bolus dosage of a treatment fluid are disclosed. A device according to embodiments of the present invention may comprise a housing comprising an external lever operable by a user, an internal lever, for applying pressure to a compression spring, which in turn may press a piston to pressurize treatment fluid contained in an internal reservoir, in a high flow rate, through a small diameter catheter, into a patient body. A system according to some embodiment may comprise a device having an external reservoir connected to an inlet thereof, and a catheter connected to an outlet thereof. A method according to some embodiments may comprise actuating levers of the device, compressing a partially loaded compression spring contained in a spring cage, and pressurizing fluid contained in an internal reservoir of the device to be released through an outlet of the device.