Invention Grant
US09573921B2 Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists
有权
取代异黄烷酮肟的N,N-二甲基氨基烷基醚作为H1-受体拮抗剂
- Patent Title: Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists
- Patent Title (中): 取代异黄烷酮肟的N,N-二甲基氨基烷基醚作为H1-受体拮抗剂
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Application No.: US15023210Application Date: 2013-09-30
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Publication No.: US09573921B2Publication Date: 2017-02-21
- Inventor: Piotr Kopczacki , Mieczyslaw Wosko , Jaroslaw Walczak , Krzysztof Walczynski
- Applicant: POLFARMEX S.A.
- Applicant Address: PL Kutno
- Assignee: Polfarmex S.A.
- Current Assignee: Polfarmex S.A.
- Current Assignee Address: PL Kutno
- Agency: Seed IP Law Group LLP
- International Application: PCT/PL2013/000126 WO 20130930
- International Announcement: WO2015/047113 WO 20150402
- Main IPC: A61K31/22
- IPC: A61K31/22 ; C07D311/58 ; C07D311/68 ; C07D407/04 ; C07D405/04

Abstract:
The present invention relates to compounds of formula (I), and salts thereof and the pharmaceutical composition containing them in treatment of various diseases, as allergic rhinitis where R1 and R2 are, independently, hydrogen, halogen, C1_3 alkyl or C1-3alkoxy; R3 is phenyl optionally substituted by R4 and R5 which are, independently hydrogen, halogen, C1-3 alkyl, C1-3-alkoxy, fluoro-, difluoro- and trifluoromethyl, nitrile group, N,N-diC1-3alkyl-amide, carboC1-3 alkoxy or C1-3alkylsulphone groups; R3 is pyridyl group containing nitrogen at various positions in the benzene ring, n is one of the integers 1 or 2.
Public/Granted literature
- US20160237055A1 NOVEL SUBSTITUTED N, N-DIMETHYLAMINOALKYL ETHERS OF ISOFLAVANONE OXIMES AS H1-RECEPTOR ANTAGONISTS Public/Granted day:2016-08-18
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